Alexander V. Zholos

Alexander V. Zholos

@ Taras Shevchenko National University of Kyiv, Ukraine

Species differences in receptor-operated TRPC4 channels

The ever-growing number of sequenced animal genomes provides a wealth of information concerning not only evolutionary relations, but also molecular structure-function relations. In this talk, our recent work on receptor-operated TRPC4 channel expressed in intestinal myocytes of rodents will be discussed in the context of the role of certain naturally occurring structural differences of these channel proteins, as well as the potential issues concerning using animal models for translational research.

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