Hydrogen sulfide to the rescue:  Trials and tribulations of translational research

Ulceration of the gastrointestinal tract by nonsteroidal anti-inflammatory drugs (NSAIDs) remains a major health problem.  We have exploited the powerful protective and repair-promoting effects of hydrogen sulfide to design new NSAIDs that are safe in the GI tract.  Translating our basic science research to clinical use has been exciting but very challenging.